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Faculty Research Interests
Adeboye
Adejare
(B.S., M.S., Iowa; Ph.D., Ohio)
Professor of Pharmaceutical Sciences
Chair, Department of Pharmaceutical Sciences
Anil
P. D'mello
(B.Pharm., KMK College, U. of Bombay; Ph.D., U. of Pittsburg)
Professor of Pharmaceutical Sciences
Research Interests
Recent epidemiological studies have shown
associations between low birth weight and increased susceptibility
to chronic disease during adulthood. The authors hypothesize
that prenatal insults program a set of cellular changes in the developing
fetus which produce low birth weight, and predispose the offspring
to chronic disease. Our laboratory is interested in examining the
effects of prenatal insults on the ontogeny of xenobiotic metabolism
and pharmacokinetics of drugs in the offspring. Specifically, we
are interested in determining if transient insults during susceptible
periods in fetal development can program alterations in drug metabolism
and pharmacokinetics which are long term, and possibly permanent.
Understanding the molecular mechanisms responsible for such alterations
is an important aspect of the research program in our laboratory.
Publications
Ruchi Shah and Anil D'mello.
Stabilization of phenyalanine ammonia lyase against organic solvend
medicated deactiviation. Int. J. Pharmaceutics under review
Genesh Cherala, Bernard H. Shapiro and
Anil P. D'mello. Differences in the effects of
two low protein diets on food consumption and reproductive performance
in pregnant and lactating rats and on long term growth of their
offspring. J. Nutrition. Provisionally Accepted, 2006
Anil P. D'mello and
Ying Liu. Effects of maternal immobilization stress on birth weight
and glucose homeostasis in the offspring. Psychoneuroendocrinology
31, 395-406 (2006).
William J. Cassano Jr. and Anil
P. D'mello. Acute stress induced facilitation of the hypothalamic-
pituitary- adrenal axis: Role of stressor duration and serotonin.
Neuroendocrinology 74, 167-177, (2001)
Susan Habibi-Moini, and Anil P. D'mello.
Evaluation of possible reasons for the low phenylalanine ammonia
lyase activity within cellulose nitrate membrane microcapsules.
Int. J. Pharmaceutics., 215:185-196 (2001).
Y. Nancy Wong, William J. Cassano Jr.,
and Anil P. D'mello, Acute Stress induced facilitation of
the hypothalamic- pituitary- adrenal axis. Neuroendocrinology,
71:354-365 (2000).
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Pardeep
K. Gupta
(B. Pharm., Panjab Univ.; M. Pharm., Panjab Univ.; M.S., PCPS; Ph.D.,
U. of Wisconsin)
Associate Professor of Pharmaceutics
Research Interests
My current research is in the area of
peptide and protein interactions with lipid and biomembranes.
We are investigating the relationship between structural properties
of peptides and their binding and permeation across lipid bilayers
and cell monolayers. Recently we have started working on a
new peptide, the Protein Transduction Domain of TAT protein, an
11 amino acid sequence, that allows non-specific entry of the attached
protein into mammalian cells. We are in the process of determining
the location and configuration of this peptide in the lipid bilayers,
which will allow us to synthesize analogues that can be used to
conjugate proteins and other biotechnology drugs for delivery through
the mucosal membranes.
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S.
(Kamal) Jonnalagadda
(B. Pharm., BIT, India; Ph.D., Univ. of Nebraska)
Assistant Professor of Pharmaceutics
Research Interests
The research focus in our laboratory
is the design, characterization, and the modeling of polymeric biomaterials
for specific pharmaceutical applications. Applications include:
(1) solid dosage forms: polymorphic transitions as a function of
excipient concentration, storage (or ageing), and during the different
stages of drug formulation, such as mixing, granulation, drying
and compression. (2) biodegradable polymeric implants for macromolecular
drug delivery and tissue engineering.
Publications
P.Park, S. Jonnalagadda.
Predictors of glass transition in the biodegradable poly-lactide
and poly-lactide-co-glycolide polymers. J. of Applied Polym
Sci., 100(3), 1983-87, 2006.
R. L. Graves, M.C. Makoid, S. Jonnalagadda.
The effect of coencapsulation of bovine insulin with cyclodextrins
in ethylcellulose microcapsules. J. Microencapsul. Accepted,
March, 2005.
S. Jonnalagadda, D.H. Robinson.
Effect of thickness and PEG addition on the hydrophilic degradation
of PLLA. J. Biomat. Sci. Polym. Ed., 15(10), 1317-26, 2004.
S. Jonnalagadda, D.H. Robinson.
Effect of the inclusion of PEG on the solid-state properties and
drug release from polylactic acid films and microcapsules. J.
Applied Polym. Sci., 93(5), 2025-30, 2004.
P. Park, S. Jonnalagadda.
Preliminary studies in the development of a flexible antibiotic
carrier to treat chronic osteomyelitis : The effect of process variables
and excipients on the thermal and mechanical properties of PLA and
PLGA copolymers, Winter Symposium and 11th International Symposium
on Recent Advances on Drug Delivery Systems, Controlled Release
Society, University of Utah Proceedings, No. 111, (March) 2003.
S. Jonnalagadda, D. H. Robinson.
A bioresorbable polylactide delivery system for diffusional and
osmotic controlled drug delivery. AAPS Pharm. Sci. Tech., 1:E29,
2000.
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Jeffrey C. Moore
(B.S., Drexel University)
Instructor in Pharmaceutics;
Manager, Industrial Pharmacy Laboratory
Research Interests
My research interests center around the
study of formulation and product development in many of the more
common pharmaceutical dosage forms. These forms are usually tablets,
capsules, semi-solid ointments and other forms. There are many factors
which go into manufacturing these drug deliver systems. To make
such dosage forms, it is necessary to use a variety of equipment
and ingredients and to follow strict rules of processing in order
to produce the best result. Then, testing is done to see if the
final form of the medication has been made accurately and is effective
and stable. Such high level machinery as tablet presses and specialized
mixers are used for this purpose. The data collected in this type
of research is then used as a guide toward the emergence of future
medications.
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Steven H. Neau
(B.S., B.A., Eastern Michigan Univ.; M.S., Ph.D., The University
of Michigan)
Professor of Pharmaceutical Sciences
Research Interests
The research conducted by my group is
in the Physical Pharmacy and Formulation Development areas. We have
explored pharmaceutical applications of polymeric materials in the
analysis and delivery of drugs. In particular, we are focusing on
the use of polymers to achieve sustained or colon-specific drug
release following oral administration of the product. Colon-specific
drug delivery is important in the treatment of localized diseases
and conditions, such as Crohn's disease, ulcerative colitis, colorectal
cancer and amoebiasis. Peptides, proteins and vaccines pose potential
candidature for colon targeted drug delivery for systemic absorption
since they are susceptible to degradation by enzymes found in the
small intestine. The polymer establishes a release controlling matrix
throughout the dosage form or only within a coating applied to the
bead or tablet. Research efforts have resulted in 46 journal articles
and book chapters, as well as 63 presentations at national and international
scientific conferences. Students involved in these research projects
have earned B.S., Pharm.D., M.S. and Ph.D. degrees and now hold
positions in academia and in the medical and pharmaceutical industry.
Publications
“Extruded and Spheronized Beads
Containing Carbopol® 974P to Deliver Nonelectrolytes and Salts
of Weakly Basic Drugs,” G. S. Bommareddy, S. Paker-Leggs,
K. K. Saripella, and S. H. Neau, Int. J. Pharm.,
In Press.
“Polyethylene Oxide and Methoxypolyethylene Glycol in the
Production of High Drug Load Extruded and Spheronized Beads That
Are Devoid of Microcrystalline Cellulose,” M. A. Howard, S.
H. Neau, and M. J. Sack, Int. J. Pharm., 307, 66-76 (2006).
“Modulating Intestinal Uptake of Atenolol using Niosomes as
Drug Permeation Enhancers,” I. A. Alsarra, A. A. Bosela, A.
M. Al-Mohizea, G. M. Mahrous, and S. H. Neau, Scientia
Pharmaceutica, 73, 81-93 (2005).
“Water Distribution Studies within Microcrystalline Cellulose
and Chitosan using Differential Scanning Calorimetry and Dynamic
Vapor Sorption Analysis,” A. M. Agrawal, R. V. Manek, W. M.
Kolling, and S. H. Neau, J. Pharm. Sci., 93, 1766-1779
(2004).
“Extruded and Spheronized Beads Containing No Microcrystalline
Cellulose: Influence of Formulation and Process Variables,”
A. M. Agrawal, M. A. Howard, and S. H. Neau, Pharm.
Dev. Technol., 9, 197-217 (2004).
“Effects of Preparative Parameters on the Properties of
Chitosan Hydrogel Beads Containing Candida Rugosa Lipase,”
I. A. Alsarra, S. H. Neau, and M. A. Howard, Biomaterials,
25(13), 2645-2655 (2004).
“Studies of the Interaction between Water and Ethylcellulose:
Effect of Polymer Particle Size,” A. M. Agrawal, R. V. Manek,
W. M. Kolling, and S. H. Neau, AAPSPharmSciTech,
4(4) Article 60 (2003) http://www.aapspharmscitech.org/view.asp?art=pt040460.
“Wet Granulation Fine Particle Ethylcellulose Tablets: Effect
of Production Variables and Mathematical Modeling of Drug Release,”
A. M. Agrawal, S. H. Neau, and P. L. Bonate, AAPSPharmSci,
5(2) Article 13 (2003) www.aapspharmsci.org/volsIssues/issueView.asp?vol=05&issue=02.
“Molecular Weight and Degree of Deacetylation Effects on
Lipase-Loaded Chitosan Bead Characteristics,” I. A. Alsarra,
S. S. Betigeri, H. Zhang, and S. H. Neau, Biomaterials,
23, 3637-3644 (2002).
“Immobilization of Lipase using Hydrophilic Polymers in the
Form of Beads,” S. S. Betigeri and S. H. Neau,
Biomaterials, 23, 3627-3636 (2002).
“In Vitro Degradation of Chitosan by Bacterial Enzymes from
Rat Cecal and Colonic Contents,” H. Zhang and S. H.
Neau, Biomaterials, 23, 2761-2766 (2002).
“A Chitosan-Containing Multiparticulate System for Macromolecule
Delivery to the Colon,” H. Zhang, I. A. Alsarra, and S.
H. Neau, Int. J. Pharm., 239, 197-205 (2002).
“Fine Particle Ethylcellulose as a Tablet Binder in Direct
Compression, Immediate Release Tablets,” R. P. Desai, S.
H. Neau, S. I. Pather, and T. P. Johnston, Drug Dev. Ind.
Pharm., 27, 35-43 (2001).
“In Vitro Degradation of Chitosan by a Commercial Enzyme
Preparation: Effect of Molecular Weight and Degree of Deacetylation,”
H. Zhang and S. H. Neau, Biomaterials, 22, 1653-1658
(2001).
"Lipase-Catalyzed Enantioselective Esterification of Flurbiprofen
with n-Butanol," S. V. Bhandarkar and S. H. Neau,
EJB: Electr. J. Biotechnol., 3(3), (Dec 15, 2000). http://www.ejbiotechnology.info/content/vol3/issue3/index.html#research.
“Evaluation of Quantitative Structure Property Relationships
Necessary for Enantioresolution with Lambda-Carrageenan and Sulfobutylether
Lambda-Carrageenan,” G. M. Beck, S. H. Neau,
A. J. Holder, and J. N. Hemenway, Chirality, 12, 688-696 (2000).
“The Optimization of Lambda-Carrageenan as a Chiral Selector
in Capillary Electrophoresis Separations,” G. M. Beck and
S. H. Neau, Chirality, 12, 614-620 (2000).
“Formulation and Process Considerations for Beads Containing
Carbopol® 974P, NF Resin,” S. H. Neau,
M. Y. Chow, G. A. Hileman, M. J. Durrani, F. Gheyas, and B. A. Evans,
Int. J. Pharm., 199, 129-140 (2000).
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Clyde M. Ofner
III
(B.S., Temple Univ.; Ph.D., Temple Univ.)
Associate Professor of Pharmaceutics;
Program Director, Graduate Program in Pharmaceutics
Research Interests
Research in my group is focused on macromolecular drug delivery for tumor therapy. There are several potential advantages that a macromolecular conjugate of an anticancer drug may have compared to the free drug. These include higher maximum tolerated doses, an enhanced local effect, and reduced side effect toxicities. We are particularly interested in the role of molecular weight and other properties using a biodegradable carrier at the cellular and tumor level. Current research projects are aimed at (1) characterizing the ability of a high molecular weight biodegradable carrier to extend circulation time of a conjugate (gelatin/doxorubicin, G-DOX) followed by enhanced tumor accumulation and intracellular uptake, (2) determining intracellular mechanistic differences between the free drug and G-DOX, and (3) design and evaluation of high dose methotrexate effects using soluble gelatin-methotrexate conjugates and microspheres.
Publications and Presentations
B. Rhodes, C.M. Ofner III, Preliminary Synthesis and Characterization of a Novel Gelatin-doxorubicin Conjugate with Acid Sensitive Release, The AAPS Journal, 9(S2): Abstract T3233 (2007).
R. Desai, N. Patel, C.S. Chen, C.M. Ofner III, Cytostatic and Cytocidal Effects of a Gelatin-Methothrexate Conjugate and Free Methotraxate on HL60 Leukemia Cells, The AAPS Journal, 9(S2): Abstract T3366 (2007).
C.M. Ofner III, Soluble Macromolecular Conjugates for Passive Tumor Targeting, Philadelphia Pharmaceutical Forum, North Wales, PA, January 11, 2007
K. Pica, R. Tchao, and C.M. Ofner III, Gelatin-Methotrexate conjugate Microspheres As a Potential Drug Delivery System, J. Pharm. Sci., 95(9): 1896-1908 (2006).
C.M. Ofner III, K. Pica, B.J. Bowman, C.S Chen, Growth Inhibition, Degradation, and Methotrexate Release Studies of Gelatin/Methotrexate Conjugates, Int.J.Pharm., 308: 90-99 (2006)
J.W. Mwangi and CM Ofner III, Crosslinked Gelatin Matrices: Release of a Random Coil Macromolecular Solute, Int. J. Pharm. 278:319-327 (2004)
C.M. Ofner III, Y.E. Zhang, V.C. Jobeck, B.J. Bowman, Crosslinking Studies in Gelatin Capsules Treated with Formaldehyde and in Capsules Exposed to Elevated Temperature and Humidity, J. Pharm. Sci., 90(1):79-87 (2001).
B.J. Bowman and C.M. Ofner III, Characterization and In Vitro Methotrexate Release from Methotrexate/Gelatin Conjugates of Opposite Conjugate Bond Polarities, Pharm. Res., 17(10):1309-1315 (2000).
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