My research has uncovered a class of compounds with significant anti-AIDS activity. Using medicinal chemical principles I am trying to design and synthesize more active members in this family. One example of these novel drugs, NCI-667951, or 2-(2-nitrophenylsulfonyl)-N, 4-dimethylaniline, is shown. Other research involves the large-scale synthesis of a key intermediate of adriamycin, a naturally occurring anti-cancer agent.

However, it should be noted that as a result of my recent appointment as an Emeritus Professor, effective in Fall 2002, I will not be accepting any new research students into my laboratory. I will continue to direct the graduate students currently working in my laboratory, and will continue to be available for consultation in my areas of expertise.

‡ Undergraduate Student
* Graduate Student

J. Tomsho‡, M. Zanger and J. McKee, 1999, "A Microscale Synthesis of 2,3-Dibromosuccinic Acid," J. Chem Ed., 76, 73-74.

R.W. Buckheit, V. Fliakas-Boltz, J.D. Russell, M. Snow, S.S. Yang, J.P. Bader, T.N. Khan*, M. Zanger, 1996, "A Diarylsulfone Nonnucleoside Reverse Transcriptase Inhibitor with a Unique Sensitivity Profile to Drug-Resistant Virus Isolates," Antiviral Chemistry & Chemotherapy, 7(5), 243-252.

M. Zanger, A.R. Gennaro, and J.R. McKee, 1993, "The Aromatic Substitution Game," J. Chem. Ed., 70, 985-6.