Research Summary
My research has two directions. The first is the chemistry and biochemistry
of Polysorbate 80 (Tween 80), one of the major surfactants and solubilizing
agents used widely in many industrial applications. At present, our
emphasis is on the synthesis of derivatives that can be used to deionize
aqueous solutions and as probes for specific ions in various solutions,
including the inside of cells. The second has to do with the synthesis
of potential anticancer and antiviral agents.
However, it should be noted that as a result of my recent appointment
as an Emeritus Professor, effective in Fall 2002, I will not be accepting
any new students into my research laboratory. I will continue to direct
the graduate student currently working in my laboratory, and will
continue to be available for consultation in my areas of expertise.
Recent or Representative Publications
Undergraduate Student
* Graduate Student
C.J. Thoman, 1999, "The Versatility of Polysorbate 80 (Tween
80) as an Ionophore," J. Pharm. Sci. 88, 258.
C.J. Thoman, 1998, "Sir Humphrey Davy and Frankenstein,"
J. Chem. Educ., 75, 496.
C.J. Thoman, L.A. Vermeulen, A.M. Coffee, R.J. DeSanto,
1993, "The Effect of Dietary Polysorbate 80 on the Serum Concentrations
of Calcium and Magnesium in the Rat," J. Agric. Food Chem.,
41, 714.
C.J. Thoman, M.A. Korpusic, M.J. Huhn, T.D. Habeeb,
D.J. Slish, 1989, "The Use of Polysorbate 80 as a Phase
Transfer Catalyst," J. Org. Chem., 54, 4476.