Joan B. Tarloff, PhD
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Joan B. Tarloff, Ph.D.
BS, MS (Toledo); PhD (Medical College of Ohio)
Professor of Pharmacology and Toxicology
Email: j.tarlof@usp.edu
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Research Interests
Areas of research interest include: (a) correlation of in vivo and in vitro expression and mechanisms of toxicant-induced injury, (b) the role of pharmacokinetic mechanisms (e.g., selective renal transport systems) in determining target organ specificity, (c) the kidney as a metabolically active organ in drug/toxicant bioactivation, and (d) the influence of disease states and pathology (e.g., hypertension, diabetes) on kidney structure and function. Many diverse chemicals, as well as long-standing diseases, impact on renal structure and function. In the case of chemicals, target organ selectivity may be due to pharmacokinetic factors that cause the kidney to accumulate and retain high concentrations of these toxicants and the ability of the kidney to metabolize these toxicants to highly reactive intermediates.
Publications
Foreman, B.D., and Tarloff, J.B. Contribution of reactive oxygen species to para-aminophenol toxicity in LLC-PK1 cells. Toxicol. Appl. Pharmacol. 230: 144-149, 2008.
Kendig, D.M., and Tarloff, J.B. Inactivation of lactate dehydrogenase by several chemicals: Implications for in vitro toxicology studies. Toxicology In Vitro 21: 125-132, 2007.
Li, Y., Bentzley, C.M., and Tarloff, J.B. Comparison of para-aminophenol cytotoxicity in rat renal epithelial cells and hepatocytes. Toxicology 209: 69-76, 2005.
Gonzalez, R.J. and Tarloff, J.B. Expression and activities of several drug-metabolizing enzymes in LLCPK1 cells. Toxicology In Vitro 18: 887-894, 2004.