Joan B. Tarloff, PhD
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Joan B. Tarloff, Ph.D.
BS, MS (Toledo); PhD (Medical College of Ohio)
Professor of Pharmacology and Toxicology
Email: j.tarlof@usp.edu
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Research Interests
Areas of research interest include: (a) correlation of in vivo and in vitro expression and mechanisms of toxicant-induced injury, (b) the role of pharmacokinetic mechanisms (e.g., selective renal transport systems) in determining target organ specificity, (c) the kidney as a metabolically active organ in drug/toxicant bioactivation, and (d) the influence of disease states and pathology (e.g., hypertension, diabetes) on kidney structure and function. Many diverse chemicals, as well as long-standing diseases, impact on renal structure and function. In the case of chemicals, target organ selectivity may be due to pharmacokinetic factors that cause the kidney to accumulate and retain high concentrations of these toxicants and the ability of the kidney to metabolize these toxicants to highly reactive intermediates.
Publications
Lash, L.H. and Tarloff, J.B. editors, Toxicology of the Kidney, 3rd edition, CRC Press. 2005.
Li, Y., Bentzley, C.M., and Tarloff, J.B. Comparison of para-aminophenol cytotoxicity in rat renal epithelial cells and hepatocytes. Toxicology 209: 69-76, 2005.
Gonzalez, R.J. and Tarloff, J.B. Expression and activities of several drug-metabolizing enzymes in LLCPK1 cells. Toxicology In Vitro 18: 887-894, 2004.
Gonzalez, R.J. and Tarloff, J.B. Evaluation of hepatic subcellular fractions for Alamar blue and MTT reductase activity. Toxicology in Vitro 15: 257-259, 2001.
Tarloff, J.B.. In Vitro Assessment of Nephrotoxicity. In: In Vitro Toxicology, 2nd Edition (S.C.Gad, editor), Taylor & Francis, New York, p. 222-274, 2000.
Hallman, M.A., Tchao, R., and Tarloff, J.B. Effects of antioxidants on para-aminophenol-induced toxicity in LLC-PK1 cells. Toxicology 156: 37-45, 2000.
Yan. Z., Nikelly, J.G., Killmer, L., and Tarloff, J.B. Metabolism of para-aminophenol by rat hepatocytes. Drug Metab. Dispos. 28: 1-7, 2000.