Diane W. Morel, PhD
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Diane W. Morel, Ph.D.
BA (Douglass); MS, PhD (Case Western)
Associate Professor of Pharmacology and Toxicology
Director of Pharmacology/Toxicology Program
Interim Assistant Dean of Curriculum and Assessment, Philadelphia College of Pharmacy
Email: d.morel@usp.edu
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Research Interests
Oxidative/nitrative stress and cellular function in chronic disease
Oxidative/nitrative stress, an imbalance in reactive oxygen and nitrogen species (ROS/RNS) and their products and cellular antioxidant defenses, is thought to play a role in the development of chronic diseases such as ischemic heart disease and age-related macular degeneration. My research is geared to further understand the mechanisms by which oxidative and nitrative species contribute to changes in cellular function in chronic disease, and how dietary components or antioxidants may protect against these changes. Current studies are focused on vascular endothelial and smooth muscle cell function as related to ischemic heart disease, and retinal pigmented epithelial cell function in age-related macular degeneration.
Selected Publications
Beauchamp, GK, RSJ Keast, DW Morel, J Lin, J Pika, Q Han, C Lee, AB Smith and PAS Breslin. (2005) Ibuprofen-like activity in extra-virgin live oil. Nature 437:45-46.
McDevitt, TM, R Tchao, EH Harrison and DW Morel (2005) Carotenoids normally present in serum inhibit proliferation and induce differentiation of a human monocyte/macrophage cell line (U937). J. Nutrition 135:160-4.
During, A, MH Hussain, DW Morel and EH Harrison (2002) Carotenoid uptake and secretion by CaCo-2 cells: B-carotene isomer selectivity and carotenoid interactions. J. Lipid Res. 43:1086-95.
Dugas, TR, EH Harrison and DW Morel (2000) Novel cell culture medium for use in oxidation experiments provides insights into mechanisms of endothelial cell-mediated oxidation of low density lipoprotein. In Vitro Cellular and Developmental Biology 36:571-577.
Dugas, TR, DW Morel and EH Harrison (1999) Dietary Supplementation with b-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low density lipoprotens. Free Rad. Biol. Med. 26:1238-44.