University of the Sciences in Philadelphia

William R. Law, PhD

William R. Law, Ph.D. Professor and Chair Department of Biological Sciences Contact Info: Office: STC 342 McNeil Science & Technology Center Voice: (215) 596-8919 Fax: (215) 596-8710 Email: w.law@usp.edu

Training and Degrees

Post-Doctoral training: Loyola University Medical Center, 1986-1988
Ph.D. University of Illinois College of Medicine at Chicago 1985
B.A. Augustana College, Rock Island, IL 1979

Prior Positions

Associate Professor of Physiology: University of Illinois at Chicago, Chicago, IL 1991-2005
Senior Scientist I: Geo-Centers, Inc. under contract to Naval Medical Research Institute, Bethesda, MD. 1989-1991
Assistant Professor, Department of Surgery, Loyola University Medical Center, Maywood, IL 1988-1989
Instructor, Barat College, Lake Forest, IL 1987-1989
Visiting Professor, Gama Filho University, Rio de Janeiro, R.J., Brasil 1985-1986
High School Teacher (basic and advanced physics) Alleman High School, Rock Island, IL 1979-1981

Membership in Professional Organizations

American Physiological Society (Full)
American Heart Association
American Diabetes Association (Professional)
International Society for Heart Research (Full)
Shock Society
Society for Critical Care Medicine (Full)

Research Interests

Our lab is investigating the role of nucleotide metabolism on integrated organ and cellular function of the heart and macrophages in inflammatory responses. Specific emphasis is focused on the role of protein-protein interactions involving adenosine deaminase in regulating responses to sepsis and septic challenges. Model systems include cell culture, isolated-perfused hearts, and rodent sepsis.

Selected Recent Publications

LAW, W.R., Conlon, B.A., and Ross, J.D. The Extracellular Cardiac Purine Metabolome in Sepsis. Shock. 28(3):259_264, 2007

Ross JD, Ripper R, Law WR, Massad M, Murphy P, Edelman L, Conlon BA, Feinstein DL, Palmer JW, DiGregorio G, Weinberg GL. Adding bupivacaine to high_K cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage. Anesthesiology, 105(4):746_52, 2006.

LAW, W.R. Adenosine receptors in the response to sepsis: What do receptor-specific knockouts tell us? American Journal of Physiology: Regulatory, Integrative, and Developmental Physiology. (In Press), 2006

LAW, W.R. Transgenic approaches to reintegration: Adenosine deaminase deficiency improves ischemic tolerance. Cardiovascular Research. 71: 8-9, 2006

Conlon, B.A., Ross, J.D., and LAW, W.R. Advances in understanding adenosine as a plurisystem modulator in sepsis and the systemic inflammatory response syndrome (SIRS). Frontiers in Bioscience 10:2548_65, 2005

LAW, W.R., Ross, J.D., and Jonjev, Z.S. Adenosine attenuates C-terminal but not N-terminal proteolysis of cTnI during cardioplegic arrest. J. Surg. Res. 123:126_33, 2005

Conlon, B.A. and LAW, W.R. Macrophages Are a Source of Extracellular Adenosine Deaminase_2 During Inflammatory Responses. Clin. Exper. Immun. 138: 14-20, 2004

Jonjev, Z.S., Schwertz, D.W., Beck, J.M., Ross, J.D., and LAW, W.R. Subcellular distribution of protein kinase C isozymes during cardioplegic arrest. J. Thoracic and Cardiovascular Surgery. 126:1880_1885, 2003.

LAW, W.R., Valli, V.E., and Conlon, B.A. Therapeutic Potential for Transient Inhibition of Adenosine Deaminase in Systemic Inflammatory Response Syndrome. Critical Care Medicine 31:1475-1481, 2003.

Cohen, E.S, LAW, W.R., Easington, C.R., Cruz, K.Q., Nardulli, B.A., Balk, R.A., Parrillo, J.E., and Hollenberg, S.M. Adenosine Deaminase Inhibition Attenuates Microvascular Dysfunction and Improves Survival in Sepsis. Am. J. Respir. Crit. Care Med. 166:16_20, 2002.